Blake was born on January 18, 1970 in Compton, California. He was chiefly inspired by funk and soul artists, such as Roger Troutman (who even taught him the use of the talkbox, which became a trademark for Quik's sound throughout his career) and George Clinton. Out of respect for his beloved friend, Roger Troutman, he retired the talkbox. David's love for music began at 2, as his mother had an extensive record collection. By age 12 he was already playing instruments, and by the age of 21, he was a platinum-selling artist.

He began selling homemade mixtapes (notably The Red Tape, 1987) after he received a turntable for his 9th grade graduation. He then began doing shows DJing around Southern California, many of which ended in rival gang related altercations.

In the 11th grade, Quik dropped out of high school. For a period of about three years he was homeless after his mother lost her home, due to foreclosure.

He would later go on to say that after his success in the rap world many of his family members "popped up".